Good Sam Club Open Roads Forum: Around the Campfire: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
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Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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silversand

Montreal

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Joined: 09/12/2004

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Posted: 08/22/22 10:20am Link  |  Quote  |  Print  |  Notify Moderator

Dateline Aug 11; update and new data on prevalence, mechanisms and biomarkers, and potential treatments for "long Covid":

here-->


Silver
2004 Chevy Silverado 2500HD 4x4 6.0L Ext/LB Tow Package 4L80E Michelin AT2s| Outfitter Caribou

silversand

Montreal

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Joined: 09/12/2004

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Posted: 08/23/22 07:31am Link  |  Quote  |  Print  |  Notify Moderator

July 19 2022

Subject of research: ....intranasal immunization; mucosal booster vaccines

"Previous studies have examined the COVID-19 mRNA vaccine induced humoral and cellular immunity in the nasal mucosa (15, 16). However, it is still controversial whether intramuscular mRNA immunization can induce meaningful neutralizing antibodies and tissue-resident T and B cells in the nasal tissue (17, 18), potentially in part due to the limited amount of fluids/cells that can be sampled in nasal washes or nasal swabs".

We focused on intranasal immunization in mRNA-immunized mice, in keeping the contention that induction of mucosal immunity likely occurs in previously vaccinated individuals who will be willing to receive mucosal booster vaccines.

Respiratory mucosal immunity against SARS-CoV-2 following mRNA vaccination

https://www.science.org/doi/full/10.1126/sciimmunol.add4853

BCSnob

Middletown, MD

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Posted: 08/23/22 11:02am Link  |  Quote  |  Print  |  Notify Moderator

Pfizer and BioNTech Submit Application to U.S. FDA for Emergency Use Authorization of Omicron BA.4/BA.5-Adapted Bivalent COVID-19 Vaccine
Pfizer Press Release

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 08/23/22 02:28pm Link  |  Quote  |  Print  |  Notify Moderator

Did these Bivalent vaccines undergo Phase II or III trials or are they piggybacking on conventional mRNA datum?

BCSnob

Middletown, MD

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Posted: 08/23/22 02:49pm Link  |  Quote  |  Print  |  Notify Moderator

I looked but have not found the published study.
Have not seen the FDAs final ruling on what studies will be required for updated Covid vaccines.

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 08/23/22 10:07pm Link  |  Quote  |  Print  |  Notify Moderator

I saw ambiguities in reports from independent medical news sources that conflict about subtypes addressed in the "updated" serums of Pfizer. None of which touches on B.A.4 or B.A.5 variants.

BCSnob

Middletown, MD

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Posted: 08/24/22 04:42am Link  |  Quote  |  Print  |  Notify Moderator

I have seen published studies (phase 2/3 trials) of Pfizer and Moderna bivalent vaccines with various combinations of wuhan, alpha, delta, or Omicron (ba.1). I’ve seen press releases about both working on vaccines with ba.4/5 but no data.

BCSnob

Middletown, MD

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Posted: 08/24/22 09:14am Link  |  Quote  |  Print  |  Notify Moderator

An FDA change to vaccine authorization allowed Pfizer and Moderna to apply for BA.5 booster approval without key data

Fortune

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 08/24/22 03:38pm Link  |  Quote  |  Print  |  Notify Moderator

https://edition.cnn.com/2022/08/23/healt........id-omicron-booster-submission/index.html

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 08/24/22 03:40pm Link  |  Quote  |  Print  |  Notify Moderator

Pfizer 30 ug Bivalent
Moderna 50 ug Bivalent

Results of Phase 2 and Three trials, peer reviews, distribution in 30 days? Hmmmmm.

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